How to delete contacts that have never opened one of my emails

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How to delete contacts that have never opened one of my emails

Hi ! recently i moved from  to Constantcontact  i had 5000 emails , now i have seen only an average of 2000 are actually reading what i send , the question is   :  how can i delete all the emails ( or unsubscribe )  that have never opened  one of my emails ???  

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