Hi @MonicaM7
That's a great question! The good news is you can add this segment into a separate contact lists. You can then delete the contacts from your account. You also have the option of exporting a copy of these segmented contacts and unsubscribing them through a bulk upload. Though it's important to point out you won't see the option to do a bulk upload of unsubscribes unless you first enable the advanced email permissions options for your account.