As someone with color-blindness (color deficiency), I find the colors selected on some of the new design make the content difficult to see.
Since 10% of all men, and 1% of women struggle with color-blindness or color-deficiency, I think it's important that this be made more accessible.
My main example is the Reporting page's Trend Overview. I specifically have green-deficient vision, so the pale green on top of the gray (my non-color blind co-worker says it's pale blue-gray) blurs together. If these colors were bolder or higher contrast, it would be far easier to see.