Hello @KatherineT834 ,
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I mean you could potentially upload a list of just contacts you already have that you want removed from the account. During the upload, create a very obviously named list (e.g. "DELETE LIST") and put the uploaded contacts into that. Then go to that list, select-all the contacts, and then delete them from your account. This will make sure that even if they're on other lists, they're still removed.
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When you upload this list, it doesn't necessarily need to have any other info, just the email addresses since that's the only required element for uploading a contact.