Update: With a list of under 10,000 (which I have right now, but won't have in about 2 weeks), I created a Suppression Tag and then tagged the customers in my Shopify Customers list that I did not want to receive a certain email. Then I set up the email, and excluded anyone that is labelled with that tag. This should work great and certainly much easier than duplicated lists and deleting people.. (SMH). BUT if you have a list of over 10,000 I haven't gotten that far with this system yet but I'm hoping that it's not a big snafu like a lot of things seem to be with this system as opposed to other ones I've used.
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