The original post in this thread focuses on segmenting your contacts into different lists based on their interests. Doing this would definitely be helpful because segments allow you to avoid sending a bulk email and send emails based on their interest instead. So you are correct, you would have to create different content based on the segment. However depending on what you have stored in your contact details, dynamic content blocks will be helpful as well. These blocks allow you to create one email with relevant content appearing for specific contacts to show based on their stored details.
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