Honestly with how Outlook renders emails using Word, there's any number of issues that may come up when they display emails in their programs, and especially between different versions of Outlook (i.e. an issue in 2016 may not occur in 2010, 2019, etc.) Since Outlook uses Word to read HTML and CSS codes for emails, it also means that emails may look drastically different at times compared to other standard email programs and apps like Gmail, Yahoo, Apple Mail, etc.
I spoke with our higher level technical team, and they've seen this issue crop up before with Outlook clients. Unfortunately with how Outlook functions, at this time those layout blocks won't appear 100% similar to how they do in the editor / preview compared to other email programs. I've tracked the known service request for this to your account, and submitted it to the engineers for further review. If and when they have an update regarding it, they'll notify you directly.
In the meantime if you're anticipating the majority of your recipients using Outlook to read your emails, I'd advise not using the sidebar layout blocks in your emails.
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